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Baste brisket with Worcestershire sauce, set aside.
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In a small bowl, mix together spices-ancho chili powder, onion powder, garlic powder, brown sugar, and salt.
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Rub brisket with the spice mix and place in the refrigerator.
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Allow to sit for at least 4 hours or up to 12 hours.
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Preheat oven to 275 degrees.
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Place 1 tablespoon of flour into a cooking bag (I used Reynold's Oven Bags).
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Add the beer and liquid smoke to the bag.
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Place brisket into the bag and tie bag closed.
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Cut 3-4 small slits in the bag.
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Place sealed bag containing brisket into a roasting pan.
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Slide roasting pan into the oven and cook for 5 hours or until tender (meat thermometer should read 185-190ºF).
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Remove from the oven and allow to sit for 20 minutes (the meat will resorb some of the juices).
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Remove from the bag and slice thinly, slicing against the grain.
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Serve with your favorite barbecue sauce!